Lung Nodules Biography
(Source google.com)
Sarcoidosis (from
sarc meaning "flesh", -oid, "like", and -osis,
"diseased or abnormal condition"), also called sarcoid, is a disease
involving abnormal collections of inflammatory cells (granulomas) that can form
as nodules in multiple organs. The granulomas are most often located in the
lungs or its associated lymph nodes, but any organ can be affected. Sarcoidosis
seems to be caused by an immune reaction to an infection or some other trigger
(called an antigen, which may be from one's environment) that continues even
after the initial infection or other antigen is cleared from the body. In most
cases it clears up by itself without any medical intervention, despite this
some cases do go on to affect the person long-term or become life-threatening
and require medical intervention, most often with medications. With an average
mortality rate of less than 5% in untreated cases. Treatment is usually
designed to help relieve the symptoms and hence do not directly alter the
course of the disease. This treatment usually consists of drugs like ibuprofen
oraspirin. In cases where the condition develops on a progressive and/or
life-threatening course the treatment is most often steroid treatment with
prednisone or prednisolone. Alternatively, drugs that are most commonly used to
treat cancer and suppress the immune system, such as methotrexate, azathioprine
and leflunomide may be used. Sarcoidosis is a systemic inflammatory disease
that can affect any organ, although it can beasymptomatic and is discovered by
accident in about 5% of cases.[ Common
symptoms, which tend to be vague, include fatigue (unrelieved by sleep; occurs
in 66% of cases), lack of energy, weight loss, joint aches and pains (which
occur in about 70% of cases), arthritis(14–38% of persons), dry eyes, swelling
of the knees, blurry vision, shortness of breath, a dry, hacking cough, or skin
lesions. Less commonly, people may cough up blood. The cutaneous symptoms vary,
and range from rashes and noduli (small bumps) toerythema nodosum, granuloma
annulare or lupus pernio. Sarcoidosis and cancer may mimic one another, making
the distinction difficult.
The combination of
erythema nodosum, bilateral hilar lymphadenopathy, and joint pain is called
Löfgren syndrome which has a relatively good prognosis. This form of the
disease occurs significantly more commonly in Scandinavian patients, than in
those of non-Scandinavian origin.
In the United States
it most commonly affects people of Northern European (especially Scandinavian
or Icelandish) or African (especially African American) ancestry between the
ages of 20 and 29, although any race or age group can be affected. Japan has a lower rate of sarcoidosis than the United States ,
although in these people the disease is usually more aggressive in its course
with the heart often affected. Japanese individuals also have a different peak
age for sarcoidosis, namely 25–40 years of age. It occurs more commonly in
women too, with the female-to-male being roughly 2:1, it also usually takes a
more aggressive course in women In developing countries it often goes
misdiagnosed astuberculosis (TB) as its symptoms often resemble those of TB. It
was first described in 1877 by an English doctor named Dr. Jonathan Hutchinson
as a skin disease causing red, raised lesions on the arms, face and hands. Localization to the lungs is by far the most common manifestation of sarcoidosis. At least 90% of affected persons experience lung involvement. Overall, about 50% develop permanent pulmonary abnormalities, and 5 to 15% have progressive fibrosis of the lungparenchyma. Sarcoidosis of the lung is primarily an interstitial lung disease in which the inflammatory process involves the alveoli, small bronchi and small blood vessels. In acute and subacute cases, physical examination usually reveals dry rales. At least 5% of persons will suffer pulmonary arterial hypertension. Less commonly, the upper respiratory tract (including the larynx, pharynxand sinuses) may be affected, which occurs in between 5 and 10% of cases.
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