Lung Biopsy Biography
(Source google.com)
A biopsy is a medical test commonly performed by a surgeon
or an interventional radiologist involving sampling of cells or tissues for
examination. It is the medical removal of tissue from a living subject to
determine the presence or extent of a disease. The tissue is generally examined
under a microscope by a pathologist, and can also be analyzed chemically. When
an entire lump or suspicious area is removed, the procedure is called
anexcisional biopsy. When only a sample of tissue is removed with preservation
of thehistological architecture of the tissue’s cells, the procedure is called
an incisional biopsy orcore biopsy. When a sample of tissue or fluid is removed
with a needle in such a way that cells are removed without preserving the
histological architecture of the tissue cells, the procedure is called a needle
aspiration biopsy. Biopsies are most commonly performed for insight into
possible cancerous and inflammatory conditions. Biopsy is of Greek origin, coming from the words bio,
meaning life, and opsia, meaning to see. French dermatologist Ernest Besnier
introduced the word “biopsy” to the medical community in 1879. When cancer is
suspected, a variety of biopsy techniques can be applied. An excisional biopsy
is an attempt to remove an entire lesion. When the specimen is evaluated, in
addition to diagnosis, the amount of uninvolved tissue around the lesion, the
surgical margin of the specimen is examined to see if the disease has spread
beyond the area biopsied. "Clear margins" or "negative
margins" means that no disease was found at the edges of the biopsy
specimen. "Positive margins" means that disease was found, and a
wider excision may be needed, depending on the diagnosis. When intact removal
is not indicated for a variety of reasons, a wedge of tissue may be taken in an
incisional biopsy. In some cases, a sample can be collected by devices that
"bite" a sample. A variety of sizes of needle can collect tissue in
the lumen (core biopsy). Smaller diameter needles collect cells and cell clusters,
fine needle aspiration biopsy. Pathologic examination of a biopsy can determine whether a
lesion is benign or malignant, and can help differentiate between different
types of cancer. In contrast to a biopsy that merely samples a lesion, a larger
excisional specimen called a resection may come to a pathologist, typically
from a surgeon attempting to eradicate a known lesion from a patient. For
example, a pathologist would examine a mastectomy specimen, even if a previous
nonexcisional breast biopsy had already established the diagnosis of breast
cancer. Examination of the full mastectomy specimen would confirm the exact
nature of the cancer (subclassification of tumor and histologic
"grading") and reveal the extent of its spread (pathologic "staging").
After the biopsy is performed, the sample of tissue that was removed from the
patient is sent to the pathology laboratory. A pathologistis a physician who
specializes in diagnosing diseases (such as cancer) by examining tissue under a
microscope. When the laboratory (see Histology) receives the biopsy sample, the
tissue is processed and an extremely thin slice of tissue is removed from the
sample and attached to a glass slide. Any remaining tissue is saved for use in
later studies, if required.
The slide with the tissue attached is treated with dyes that stain the tissue, which allows the individual cells in the tissue to be seen more clearly. The slide is then given to the pathologist, who examines the tissue under a microscope, looking for any abnormal findings. The pathologist then prepares a report that lists any abnormal or important findings from the biopsy. This report is sent to the physician who originally performed the biopsy on the patient.
The slide with the tissue attached is treated with dyes that stain the tissue, which allows the individual cells in the tissue to be seen more clearly. The slide is then given to the pathologist, who examines the tissue under a microscope, looking for any abnormal findings. The pathologist then prepares a report that lists any abnormal or important findings from the biopsy. This report is sent to the physician who originally performed the biopsy on the patient.
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